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Should I lay it on the line and tell them the way it really is or do I kind of downplay it. Here are the authors. It's more than a coincidence that many of the most expensive medications happen to be those medications that are most heavily advertised.
DR. GRAHAM: Direct-to-consumer advertising in general is a great disservice to the American people.
For every Senator in the Senate, many more people in their state died because of Vioxx or had a heart attack because of Vioxx. Currently, the way the incentives are for industry, it's safer to do a “me too” drug, another drug in the same class.
This guy has told the truth. The FDA knew there was a problem with Vioxx.
There are many classes of drugs where we've got 10 or 15 members of that class.
It's a really pernicious system. Seniors who may have trouble taking care of themselves might simply not get to a doctor.
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If the FDA says that the drug will have a particular effect, probably for many of the patients who take the drug it will actually have that effect. It's not saying I'm a saint, because I'm not. This is another way that the FDA has betrayed the American public and has betrayed the public health. Of course companies aren't going to go along with that and the FDA isn't going to do anything that's going to harm corporate profit.
Vaccination doesn. Whoever wrote that commercial should write Hallmark movies.
GRAHAM: I think that I was afraid that there would be a disaster, but I only became aware of this with the publication of the VIGOR Study, which was this large clinical trial that was done that showed that Vioxx increased the risk of heart attack five fold. Congress is going to have to make them happen. That's why they do it. Frequently what will happen is that these medical officers in their review will recommend that a drug not be approved and they get overruled by the higher ups because the higher ups are answering to a different set of incentives. He pays over $600 / month just for his drugs, and his health insurance is now up to $900 / month.
If you want to talk about breakthrough drugs – the ones that really make a difference in patients' lives and represent a revolution in pharmacology – we're talking about maybe one or two drugs a year. The standard that the FDA uses to approve a drug is primarily “does the drug work. And it's all because of this little pill that they're taking. No. Both are almost always intended to look "cool.
Clearly Vioxx was the problem. Well, I had recommended a restricted distribution system 15 years ago.